Diseases, Conditions, Syndromes

New clinical practice guideline on community acquired pneumonia

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In its latest clinical practice guideline on community-acquired pneumonia the American Thoracic Society’s guidelines panel addresses the use of nucleic acid-based testing for non-influenza viral pathogens. The guideline was published online in the May 1 issue of the American Journal of Respiratory and Critical Care Medicine.

Community-acquired pneumonia is caused by a wide range of respiratory pathogens, prominently including viruses. However, the only viral pathogen addressed by the 2019 clinical practice guideline was influenza. The panel determined that, given the increasing recognition of non-influenza viral causes of CAP and the expanded availability of diagnostic tests among clinicians, it was necessary to update the previous guideline to help guide treatment.

Using the Grading of Recommendations, Assessment, Development and Evaluation or GRADE framework, the panel made the following recommendations regarding the use of nucleic acid-based viral diagnostic testing for viral pathogens other than influenza in patients with suspected CAP:

Recommendation 1

In outpatients with suspected CAP, we suggest not performing routine nucleic-acid based testing of respiratory samples for viral pathogens other than influenza (conditional recommendation, very low-quality evidence)

Recommendation 2

In hospitalized patients with suspected CAP, we suggest nucleic acid-based testing of respiratory samples for viral pathogens other than influenza only in patients that meet one of the following conditions:

* Patients with severe CAP

* Immunocompromised patients (including neutropenia, active cancer therapy, history of solid organ or blood component transplant, advanced HIV disease, or chronic use of immunosuppressive medications including systemic corticosteroids). (conditional recommendations, very low-quality evidence)

“Molecular diagnostics for lung infections are rapidly evolving. We will continue to monitor developments to determine when additional updates are appropriate,” noted guideline panelists Scott Evans, MD and Charles Dela Cruz, MD, PhD. “We also look forward to reviewing more literature that directly link the use of molecular diagnostics on important outcomes, such as death, morbidity, antimicrobial drug use patterns, and costs.”

The ATS has published more than 20 clinical practice guidelines on various conditions, ranging from allergy and asthma to TB and other pulmonary infections. For ATS guideline implementation tools and derivatives, go here.

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More information:
Scott E. Evans et al. Nucleic Acid–based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline, American Journal of Respiratory and Critical Care Medicine (2021). DOI: 10.1164/rccm.202102-0498ST

New clinical practice guideline on community acquired pneumonia (2021, May 4)
retrieved 4 May 2021
from https://medicalxpress.com/news/2021-05-clinical-guideline-pneumonia.html

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