Diseases, Conditions, Syndromes

Lockdown during the COVID-19 pandemic: impact on infants with pyloric stenosis

The COVID-19 pandemic has posed challenges for the delivery of healthcare for infants with disruption to 6-week health checks and health visitor services.1 An area of particular concern is late presentation to the hospital.2 However, current data do not offer an objective picture of how significant a problem this may be, with other reports showing low rates of delays in presentation.3 Infantile hypertrophic pyloric stenosis (IHPS) is a common, non-infective infantile condition with a predictable clinical course and therefore a good indicator condition to assess for delays in presentation. We aimed to assess whether infants with IHPS presented later during ‘lockdown’ compared with the same period the preceding year.

Ten centres within the UK (England, Scotland and Northern Ireland) contributed data from babies with IHPS via a website (covidinchildren.co.uk) between 23 March 2020 and 31 May 2020 (the COVID-19 lockdown period) and between 23 March and 31 May 2019 (controls). A total of 87 eligible infants were included, comprising 40 controls (46%) and 47 cases (54%). The demographic and baseline characteristics of the two groups were similar (table 1 and figure 1).

Table 1

Characteristics of control (2019 patients) and lockdown (2020) patients

Figure 1

Comparison between the age at presentation (A) and admission weight (B) of infants with IHPS in the control period (2019) and the lockdown period. No significant difference is seen between the two groups (age at admission p=0.64, admission weight p=0.84). IHPS, Infantile hypertrophic pyloric stenosis.

Median age and weight at presentation in the control group were 31 days (24–41) and 3600 g (3190–4081), and those in the lockdown group were 34 days (26–41) and 3580 g (3120–4085). These differences were not statistically significant (p=0.64, p=0.84) (figure 1). The change in standardised weight loss was also comparable. (table 2). Patients requirement for preoperative intensive care and serum biochemistry was also similar except the lockdown group had a statistically but not clinically significant higher serum potassium (4.16 vs 4.5 mmol/L, p=0.04) (table 2).

Table 2

Comparison of the primary and secondary outcome measures for infants presenting during the lockdown and control periods

As an indicator condition, we have some reassurance that infants with IHPS have not had a significantly delayed presentation due to the COVID-19 lockdown. A recent objective study looking at paediatric presentations to emergency departments found very low numbers of delayed presentations to the hospital, with minimal associated morbidity.3 4 Prompt, proactive changes to National Health Service 111 algorithms, guidance for parents by the Royal College of Paediatrics and Child Health5 and the rapid uptake of virtual general practice and health visitor consultations may have avoided morbidity. Further work, focusing on different types of conditions, or different subsections of society will help provide useful information relating to the impact of societal lockdown on healthcare-seeking behaviour in the UK and will enable more effective delivery of healthcare provision and public messaging in the event of further lockdowns.

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