Aspirin not as effective as anticoagulation

Credit: CC0 Public Domain

In a multicenter study led by the University Hospital and the University Geriatric Medicine FELIX PLATTER Basel, a research group with participation from University of Basel, Inselspital, Bern University Hospital, the University of Bern and other centers, has investigated the equivalence of aspirin to anticoagulation. The study shows that aspirin is not as effective as blood thinning (anticoagulation) in the case of cervical artery dissection.

Ruptures of the carotid artery (cervical artery dissection) are the most common cause of stroke in people under 50 years of age, with an annual incidence of 2-3 cases per 100,000 persons. Salicylic-acid preparations (acetylsalicylic acid: aspirin, Aspegic) and blood-thinning medication (anticoagulants) are used for treatment. The multicenter therapy study “Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection (TREAT-CAD, NCT02046460)” investigated whether dissections—tears in the wall of vessels supplying blood to the brain—can be treated with aspirin or whether more complex blood thinning (anticoagulation) is necessary. The study was published in The Lancet Neurology on March 23, 2021.

Aspirin not equally effective

Nearly 200 patients took part in the study. The evaluation showed that in the group treated with aspirin, 23 percent had subsequent problems compared with just under 15 percent in the group treated with blood thinners. This is the first scientific study to show that in the first 90 days aspirin is not as effective as blood thinning with anticoagulation.

A broad-based study

The international study was conducted at ten centers, seven in Switzerland, two in Germany and one in Denmark. The study was led by Prof. Dr. Stefan Engelter (University Geriatric Medicine FELIX PLATTER, UAFP and University Hospital Basel, USB). He was supported by Dr. Christopher Traenka (UAFP, USB), Prof. Dr. Philippe Lyrer (USB), and Prof. Dr. Marcel Arnold (Inselspital Bern, Bern University Hospital and University of Bern).

Impact on guidelines expected

The study suggests that the evidence to consider aspirin as standard of care in patients with cervical artery dissection is insufficient. Aspirin cannot simply replace conventional standard therapy with a blood thinner. With the results of this study, however, a general superiority of blood thinning with anticoagulation has not yet been proven. The investigation of further aspects and a review of the benefit-risk profiles must provide more precise information.

Aspirin, anticoagulants similarly prevent VTE after TKA

More information:
Stefan T Engelter et al. Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial, The Lancet Neurology (2021). DOI: 10.1016/S1474-4422(21)00044-2

Provided by
Inselspital, Bern University Hospital

Aspirin not as effective as anticoagulation (2021, March 24)
retrieved 24 March 2021

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

Source link

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to top button

Ad Block Detected

Welcome to Mediexpose, Please support our journalism by allowing ads. With support from readers like you, we can continue to deliver the best. You can support us free by simply allowing ads.