Subgingival periodontal dysbiosis was linked to markers of amyloid beta, but not tau, in cognitively normal older adults. (Alzheimer’s and Dementia: Diagnosis, Assessment, and Disease Monitoring)
Imaging studies showed neural correlates of anhedonia in people with frontotemporal dementia. (Brain)
Markers of inflammation in cerebrospinal fluid showed distinct patterns in frontotemporal dementia and in early and established Alzheimer’s disease. (Journal of Alzheimer’s Disease)
The phase II KINETIC study of SAGE-324 led to a significant reduction in upper-limb tremor severity compared with placebo in adults with essential tremor, Sage Therapeutics and Biogen said, but trial participants experienced somnolence and dizziness.
Akili Interactive will work with Weill Cornell Medicine/NewYork-Presbyterian Hospital and Vanderbilt University Medical Center to evaluate a therapeutic video game to improve attention in people with COVID brain fog.
The newest patients in cognitive rehabilitation programs aren’t there because they’ve had concussion or stroke; they’re recovering from COVID-19. (Wall Street Journal)
Lobar microbleeds and plasma amyloid beta 40 were associated with cognitive decline in Parkinson’s disease. (Nature Scientific Reports)
Selective removal of astrocytic APOE4 protected mice against tau-mediated neurodegeneration and decreased synaptic loss. (Neuron)
Machine learning classified multiple sclerosis patients into one of three MRI-based subtypes — cortex-led, normal-appearing white matter-led, and lesion-led — that progressed and responded to treatment differently. (Nature Communications)
The brain of Phillip Adams, the former NFL player identified as killing six people including a local doctor in South Carolina before dying from a self-inflicted gunshot wound, will be examined for chronic traumatic encephalopathy. (Washington Post)
Can monthly cash payments to poor families promote healthy brain development in children? (New York Times)